Case ID: 23-033
Web Published: Mar 01, 2011
Available for: Exclusive licensing
Maleimides are widely considered the most selective functional group for thiol modification. Fine chemicals companies typically offer more than 50 maleimide-based products, and many more which are manufactured using them. Maleimides react irreversibly with thiols preventing controlled disassembly of conjugates, and they contain a single point of attachment for a functional moiety (such as flourophore, biotin, etc).
Maleimides are widely used and considered very effective in their standard role. They offer the ability to irreversibly bind a single functional moiety. Our patented technology is a novel class of maleimides, which permit reversible binding, and offer multiple attachment points. We believe this technology has wide-ranging applications.
Maleimides are widely used by chemical companies to enable the linkage of reagents to molecules, especially to proteins via thiol binding. This technology has primary utility for a retailer of fine chemicals through:
-Expansion of the existing product line to include multiply bound/reversible moieties
- New product lines utilising multiple functional moieties connected via maleimide (for example a fluorescent tag & biotin linked to an antibody).
There are wider applications for this technology in other areas, especially biopharmaceuticals.
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